Vitamin D3 + K2 for Heart Health

TL;DR: Vitamin D receptors are present throughout the cardiovascular system. Maintaining adequate levels supports healthy blood pressure, reduces arterial stiffness, and lowers risk of major cardiovascular events — particularly valuable in New Zealand’s latitude where deficiency is common.

Evidence rating: ⭐⭐⭐⭐⭐ Robust

Why Vitamin D3 + K2 Matters for Heart Health

New Zealand’s southern latitude means many Kiwis have suboptimal vitamin D levels for much of the year. The D-Health trial, conducted at a similar latitude, provides some of the strongest real-world evidence for cardiovascular benefits of vitamin D supplementation in populations like ours.

Key Study: Thompson, B. et al. (2023). Effect of Vitamin D Supplementation on Major Cardiovascular Events: D-Health Randomised Controlled Trial. BMJ, 381, e075230. https://doi.org/10.1136/bmj-2023-075230 — over 21,000 participants at similar southern latitude to NZ; vitamin D supplementation reduced major cardiovascular events by 9%.

Supporting evidence: van Ballegooijen, A.J. et al. (2017) highlighted the synergistic role of D3 + K2 in both bone mineralisation and arterial health — K2 helps prevent calcium deposition in blood vessels while D3 supports overall cardiovascular function.

This is not medical advice. BioHackNZ provides general information based on published research. Always consult your healthcare provider before starting any supplement regimen. Individual results vary.

Last updated: 18 May 2026 | BioHackNZ Research Team

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